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Pipeline
Venadaparib (IDX-1197) is a potent PARP inhibitor that prevents the repair of DNA single-strand breaks (SSB) and promote the conversion of SSB to double-stranded breaks (DSB), which ultimately leads to synthetic lethality in cancer cells. IDX-1197 is under clinical development targeting multiple solid tumors as a monotherapy (including maintenance) and for combination with other anti-cancer agents.
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Development of Venadaparib, a novel, selective, and highly potent PARP inhibitor

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A comparative preclinical study of PARP inhibitors demonstrates superb properties for Venadaparib

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